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Proving the transfer of cells


George Snell
Avrion Mitchison Scientist
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I had the honour of writing George Snell's biographical memoir in the PNAS last year, so I'm pretty familiar- I became familiar with his work. And he was approaching the H2 complex from a rather different angle. He was interested in transplantation factors. He had worked with Gorer defining antigens associated in the MHC in, I would say, using his terminology, within the H2 complex. But he knew that the H2 complex was multigene. He knew that, quite soon, from purely genetical experiments. And, we now know that the antigens which Gorer had looked at were what would now be called MHC class 1 genes and they're not the only genes involved in rejecting tumors. It all was getting quite complicated, and George was sorting it out.

Avrion Mitchison, the British zoologist, is currently Professor Emeritus at University College London and is best known for his work demonstrating the role of lymphocytes in tumour rejection and for the separate and cooperative roles of T- and B-lymphocytes in this and other processes.

Listeners: Martin Raff

Martin Raff is a Canadian-born neurologist and research biologist who has made important contributions to immunology and cell development. He has a special interest in apoptosis, the phenomenon of cell death.



Listen to Martin Raff at Web of Stories



Duration: 1 minute, 10 seconds

Date story recorded: June 2004

Date story went live: 24 January 2008