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Jan Klein, Milan Hasek and Miroslav Holub


Back to UCL
Avrion Mitchison Scientist
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After a year spent intermittently in NIH learning lots of new things but really not doing anything- something substantial myself, I came back to University College which has very kindly allowed me to sit at a desk in their old department, and the main part of my life has been to- and a total joy it has been- has been to get to know and to a limited extent to work with Järgen Roes who is a product of the Rajewsky School, so we start with a common background and Järgen is a terrific molecular geneticist, and I've very much enjoyed being a sort of loose attachment in his group, and to occupy myself- and actually occupying quite fully- I have been sequencing more mouse promoters, The work from Roland and his students in Berlin ended up with three- six- nine- twelve- promoter sequences. It is now up to- I've taken it up to- about a hundred or so altogether, maybe a little bit more, and that has been partly thanks to Jan Klein, a great man who I could have mentioned earlier, who- one of his great activities has been to rescue mouse MHC genes from wild mice and cross them on to laboratory strains so the mice can breed easily, and he gave me the collection of DNA that I needed for- to expand or to help expand this collection of promoters. And they have been brought into order and I hope that that has set the scene for a possible- for functional testing- this well organised group of MHC2 promoters and perhaps the TH1/TH2 theory will survive or perhaps it won't, we'll see.

Avrion Mitchison, the British zoologist, is currently Professor Emeritus at University College London and is best known for his work demonstrating the role of lymphocytes in tumour rejection and for the separate and cooperative roles of T- and B-lymphocytes in this and other processes.

Listeners: Martin Raff

Martin Raff is a Canadian-born neurologist and research biologist who has made important contributions to immunology and cell development. He has a special interest in apoptosis, the phenomenon of cell death.



Listen to Martin Raff at Web of Stories



Duration: 2 minutes, 39 seconds

Date story recorded: June 2004

Date story went live: 29 September 2010